Influence of plant extracts on insulin resistance in experimental diabetes mellitus

Objective . The aim of the study was to evaluate effect medicinal plant extracts on insulin sensitivity in model diabetes mellitus. Material and Methods Experiments were carried out using 110 outbred white male rats. Diabetes mellitus induced by administration streptozotocin animals receiving food with a high fat content for formation resistance. injected metformin, rosiglitazone, aqueous nettle, dandelion, burdock, Galega officinalis. rats divided into two groups during pharmacotherapy: group 1 continued receive fat-enriched diet; 2 received regular diet 8% content. blood levels glucose, glycated hemoglobin, triglycerides, high-density lipoprotein cholesterol measured. metabolic index calculated assess Results nettle burdock reduced concentration glucose hemoglobin treated food. Dandelion extract did not change level fasting whereas it lowered glycohemoglobin. officinalis, dandelion concentrations normal diet. all plants hemoglobin. triglycerides normalized regardless when introduced. increased both diets officinalis extracts. 8%-fat differ from that intact after therapy alleviated resistance continuing enriched fats. Conclusion improved carbohydrate lipid metabolism caused same extent as metformin rosiglitazone. Extracts